ProVET Moxistop Maxi Tablets for Dogs 20kg for Treatment and Prevention of Helminthiasis 2pcs

Prevention and treatment in nematodes (Toxocara cati, Toxascaris leonine, Ancylostoma tubaeforme, Ucinaria stenocephala, Trichuris vulpis, Angiostrongylus vasorum, Crenosoma vulpis, Thelaria callipaeda), cestodiasis (Dipylidum caninum, Echinococcus granulosus, Echinococcus multilocularis, Taenia pisiformis, Taenia hydatigena, Mesocestoides spp.) and multimodal nematodes-cestodiasis invasions, as well as prevention of dirofilariasis. 

“Moxistop” maxi is related to composite antiparasitic preparations. The combination of moxidectin and praziquantel, which are a part of preparation, provides broad-spectrum antiparasitic effect, as well on larval and mature stages of intestinal nematodes development (Toxocara cati, Toxascaris leonine, Ancylostoma tubaeforme, Ucinaria stenocephala, Trichuris vulpis), larvae (microdirofilaria) nematodes of Dirofilaria immitis, Dirofilaria repens, Thelaria callipaeda, cestodes (Dipylidum caninum, Echinococcus granulosus, Alveococcus multilocularis, Mesocestoides lineatus, Diphyllobothrium latum, Multiceps multiceps), which are parasitized on dogs.

Moxidectin is a synthetic derivative of another generation of macrocyclic lactones in the milbemycin group. Actual substanceis is active against endoparasites. Its mechanism of action is due to the interaction of gamma-aminobutyric acid and glutaric chlorine channels of parasites, which leads to the opening of chlorine channels in the postsynaptic space and increase chlorine ions, resulting in irreversible decrease in muscle activity, paralysis and death of parasites. Excreted from the body in the same way as faeces.

Praziquantel is active of cestodes (tapeworms), inducing increase of muscles activity, which is changed by muscle contraction and spastic paralysis, resulting destruction of mature cestodes external covering. Tapeworms almost digested and are not detected in faeces under the action of praziquantel.

Praziquantel is absorbed in the digestive tract, reaching its maximum concentration in blood plasma in 1-3 hours, distributed in animal organs and tissues, excreted mainly in the urine (up to 80%) within 48 hours). The drug according to the degree of action on the body belongs to low-risk substances (safety class 4), has weak cumulative properties, in the recommended doses has no embryotoxic and teratogenic effects.

The drug is toxic to bees, fish and other aquatic organisms!